Over 50% of GLP-1
weight loss patients
discontinue treatment within 12 months
Source: Evernorth Research Institute, 2025 Pharmacy in Focus Report
More than 30%
drop out
within the first four weeks — before reaching therapeutic dose
Source: Blue Health Intelligence study, ~170,000 commercial health plan members
Top reasons for
discontinuation:
side effects (43.7%), cost/insurance barriers (30.9%), adherence challenges (15.3%)
Source: Evernorth Research Institute, 2025